What is it about?
We assayed the soluble counterparts of 12 biomarkers of immune response in 113 internal medicine patients with bacterial sepsis. IRAK-M exhibited the highest HRs for increased 7-day (1.94; 95% CI, 1.17–3.20) and 30-day mortality (1.61; 95% CI, 1.14–2.28). HRs of IRAK-M and galectin-1 for predicting 1-year mortality were 1.52 (95% CI, 1.20–1.92) and 1.64 (95% CI, 1.13–2.36), respectively.
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Why is it important?
Two inhibitory immune checkpoint biomarkers (IRAK-M and galectin-1) helped identify 3 distinct sepsis phenotypes with distinct prognoses. These biomarkers shed light on the interplay between immune dysfunction and prognosis in patients with bacterial sepsis and may prove to be useful prognostic markers, therapeutic targets, and biochemical markers for targeted enrollment in therapeutic trials.
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This page is a summary of: Inhibitory Immune Checkpoints Predict 7-Day, In-Hospital, and 1-Year Mortality of Internal Medicine Patients Admitted With Bacterial Sepsis, The Journal of Infectious Diseases, July 2024, Oxford University Press (OUP),
DOI: 10.1093/infdis/jiae370.
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