What is it about?
In this study we analyzed whether RNAse7 was involved in the immunity against tuberculosis, our findings show that this antimicrobial peptides is used by lung epithelial cells and macrophages to eliminate mycobacteria. Our results show that this peptides bind to mycobacteria and promotes its killing.
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Why is it important?
In the last decade the emerging of multidrug resistant strains has darken the future for tuberculosis therapy. In this reports we shoed that RNAse7 is important for Mtb elimination thus could be a future candidate for therapy.
Perspectives
Antimicrobial peptides are important molecules of the immunity, however scarce information is available in tuberculosis, it is important to keep investigating the importance of these molecules not only in tb but in other infectious diseases
Bruno Rivas-Santiago
Instituto Mexicano del Seguro Social
Read the Original
This page is a summary of: RNase 7 but not psoriasin nor sPLA2-IIA associates with Mycobacterium tuberculosis during airway epithelial cell infection, Pathogens and Disease, January 2018, Oxford University Press (OUP),
DOI: 10.1093/femspd/fty005.
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