What is it about?
Nowadays, regenerative cardiology is focusing on growth factors therapy. Some studies have shown that growth factors such as Insulin-like Growth Factor 1 (IGF-1) or Hepatocyte Growth Factor (HGF) could have antifibrotic, angiogenic and antiapoptotic properties. Furthermore, microencapsulation of these growth factors allows a sustained release over time with a single intervention.
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Injection was successful in all cases in absence of major adverse cardiac events. No changes to the ECG were seen in any case. TIMI flow decreased to TIMI 1 or 2 in three animals from the HGF group and four belonging to the IGF-1 group. These changes were not accompanied by increases in TnI values in any group. Treatment effect on EF (ΔEF) was significantly higher in IGF-1 animals. The effect of the treatment on EDVi and ESVi was not significantly different between groups. TTC staining showed more viable tissue within the infarct zone in IGF-1 than in HGF-treated animals.
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This page is a summary of: P1739Comparison of intracoronary administration of microspheres loaded with either insulin-like growth factor 1 or hepatocyte growth factor in a swine acute infarct model, European Heart Journal, August 2017, Oxford University Press (OUP),
DOI: 10.1093/eurheartj/ehx502.p1739.
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