What is it about?
Central carbon metabolism and DNA replication are two essential cellular processes. We have shown for the first time that the two processes are functionally connected by multiple links in the bacterium Bacillus subtilis.
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Why is it important?
Two significant findings are that, in rich media: (i) eleven genes of central carbon metabolism are important for a proper temporal control of DNA replication in the cell cycle of Bacillus subtilis and (ii) central carbon metabolism may affect initiation by altering the functional recruitment of initiation factors at replication origins and/or may affect DNA elongation by altering lagging strand synthesis.
Perspectives
This article opens routes to a new, universal signaling system that modulates the initiation and elongation phase of replication according to the activity of key determinants (enzymes and/or metabolites) of central carbon metabolism. This would assign a replication function to central carbon metabolism that may be of great importance in cancer. Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations.
Dr Laurent Janniere
Genopole, CNRS, UEVE, Paris-Saclay
Read the Original
This page is a summary of: OUP accepted manuscript, DNA Research, January 2018, Oxford University Press (OUP),
DOI: 10.1093/dnares/dsy031.
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