What is it about?
The results from the proteomic analysis of extracellular vesicles from endometrial-derived mesenchymal stem cells (EV-endMSCs) and the classification by Reactome pathways allowed us to identify proteins closely related with the fertilization process. Moreover, the supplementation of the embryo culture medium with EV-endMSCs improved the developmental competence of the embryos as well as the total blastomere count.
Featured Image
Why is it important?
We demonstrate that EV-endMSCs increase the quality of the embryos, and according to proteomic and genomic analysis, presumably by modulating the expression of antioxidant enzymes and promoting pluripotent activity. Therefore, EV-endMSCs could be a valuable tool in human assisted reproduction improving the developmental competence of aged oocytes and increasing the odds of implantation and subsequent delivery.
Read the Original
This page is a summary of: Extracellular vesicles derived from endometrial human mesenchymal stem cells enhance embryo yield and quality in an aged murine model†, Biology of Reproduction, December 2018, Oxford University Press (OUP),
DOI: 10.1093/biolre/ioy263.
You can read the full text:
Resources
Contributors
The following have contributed to this page
