What is it about?
Explains the mechanism by which 14-3-3 can activate or inhibit b-catenin co-transcriptional activity.
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Why is it important?
First paper to demonstrate that a simple fosforilation in 14-3-3 proteins controls the intracellular distribution of 14-3-3 and its binding partners.
Perspectives
We believe that the findings in this paper describe a mechanism that can explain how stemness is maintained in the colon.
Porfirio Nava
Centro de investigacion y estudios avanzados del IPN
Read the Original
This page is a summary of: IFN -induced suppression of -catenin signaling: evidence for roles of Akt and 14.3.3 , Molecular Biology of the Cell, July 2014, American Society for Cell Biology (ASCB),
DOI: 10.1091/mbc.e13-09-0512.
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