What is it about?
PCNA is a key protein in the nucleus. It acts as a molecular tool belt and as such interacts with a range of different proteins to facilitate a gaiety of process, including DNA replication and DNA repair. This paper describes the modification of PCNA by a small protein -ubiquitin. We demonstrate that this is required for a post-replication repair process in fission yeast.
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Perspectives
Ubiquitination of PCNA has been analysed in budding yeast (s. cerevisiae) as well as in mammalian cells. Although PCNA and ubiquitin are highly conserved, it appears that there are subtle differences in the role of ubiquitination on PCNA function in the different organisms. In other organism, PCNA has also been demonstrated to be sumoylated- we are interested in determining whether this is also the case in S. pombe.
Dr Felicity Z Watts
University of Sussex
Read the Original
This page is a summary of: Postreplication Repair and PCNA Modification in Schizosaccharomyces pombe, Molecular Biology of the Cell, April 2006, American Society for Cell Biology (ASCB),
DOI: 10.1091/mbc.e05-11-1008.
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