What is it about?
Metallo-beta-lactamases (MBL) are zinc-depending enzymes. We demonstrated that zinc chelators (TPEN and nitroxoline) can restore meropenem activity against MBL-producing bacteria (in vitro), increasing the survival of infected animals (Galleria mellonella)
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Why is it important?
Zinc chelators may be helpful adjuvants against MBL infections, and they need to be studied in humans
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This page is a summary of: Zinc Chelators as Carbapenem Adjuvants for Metallo-β-Lactamase-Producing Bacteria: In Vitro and In Vivo Evaluation, Microbial Drug Resistance, May 2020, Mary Ann Liebert Inc,
DOI: 10.1089/mdr.2020.0037.
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