Mammalian Sulfur Amino Acid Metabolism: A Nexus Between Redox Regulation, Nutrition, Epigenetics, and Detoxification

What is it about?

The review shows the interplay between Nutrition and the production of key metabolites that participate in important cellular events. Aspects as how methionine ingestion is related to longevity or the impairment of key metabolic pathways involving sulfur amino acids in disease are explored. Moreover, the current knowledge on the main characteristics of the enzymes involved in these processes, the regulation of their expression and activity, as well as other essential features for their correct function are explained. Overall, redox regulation controls all these linked processes at several levels that include among others gene expression, protein activity and association, or subcellular localization.

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Why is it important?

The review offers a complete view of the current knowledge on the interplay between essential cellular events such as epigenetics or detoxification and sulfur amino acids. Moreover, sulfur amino acids and their related metabolites act as links between these processes that, in turn exert regulatory actions on their metabolism.