Biocompatible fluorescent nanoparticles and stem cell tracking

What is it about?

The lack of effective treatments for neurodegenerative diseases prompted scientists to study stem cells as a feasible therapeutic alternative. However, an important challenge is to safely track cells to follow their fate. In this work we synthesized stable fluorescent methyl methacrylate nanoparticles, which combines magnetic properties and fluorescence, and tested them for direct visualization. Our results show these nanoparticles are stably and easily detectable with multiple methods.

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Why is it important?

Our work shows that fluorescent and magnetic nanoparticles detectable with multiple methods are an efficent alternative to classical magnetic nanoparticles reducing time consuming analyses. We set up an efficient protocol to visualize cells in vitro and upon graft which can be used for future efficient therapeutic strategies applicable to patient.