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This is the first report that IgM B cells, previously thought of as naive cells that haven't reacted to antigen yet, are not all naive. Some specialised cells show evidence of activation that is normally seen in memory cells. Later evidence since this publication leads us to suspect that these cells may be responding to infectious challenge in a different manner, without the direct help from T cells.
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This page is a summary of: Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells, The Journal of Experimental Medicine, August 1995, Rockefeller University Press,
DOI: 10.1084/jem.182.2.559.
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