photosensitizer encapsulated by silica nanoparticles

What is it about?

Achieved Silica Nanoparticles (SiNPs) to encapsulate the photosensitizer [Protoporphyrin IX (PpIX)] in photodynamic therapy (PDT) application was reported in this research. Cytotoxicity for five different concentrations of encapsulated and naked PpIX was measured. Optimum concentration and optimum exposure time of encapsulated and naked PpIX that needed to destroy the cells (Osteosarcoma cells) was measured. The results showed that the encapsulated PpIX has more efficacy compared to the naked PpIX and the applicability of the encapsulated PpIX-SiNPs was proved on osteosarcoma cells.The results established the important in-vitro photodynamic effectiveness of PpIX-SiNP, which may open a new application for PpIX in its clinical and in-vitro studies.

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Why is it important?

The physical effects of encapsulated of the PS by SiNPs to be one of the main photodynamic applications were discussed. The encapsulated PSs have more efficacies compared to the naked PSs and the applicability of the encapsulated PSs was proved on osteosarcoma cells. The results showed the importance of in vitro photodynamic effectiveness for encapsulated PSs. Encapsulated PS has cytotoxicity on the osteosarcoma cells higher than naked PSs, which can be used to conclude that the encapsulation reduced the PS toxicity but the chemicals, which used for SiNPs synthesis, increased the cytotoxicity

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