What is it about?
The gene regulatory network-based approach provides detailed features of the molecular mechanisms and related pathways in responding to graphene oxide treatment.
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Why is it important?
The toxicity of nanoparticles has a considerable impact on the levels and functions of miRNAs. The specific toxic properties via microRNA-graphene oxide interactions support biomedical applications of graphene oxide in cancer therapy.
Perspectives
The importance of miRNAs in cancer biology as therapeutic targets, and through regulation of their target genes, suggests further investigations on the interplay between graphene oxide and miRNAs using systems biology and pathway based approaches.
Masoumeh Farahani
shahid beheshti university of medical sciences
Read the Original
This page is a summary of: Deciphering the transcription factor-microRNA-target gene regulatory network associated with graphene oxide cytotoxicity, Nanotoxicology, October 2018, Taylor & Francis,
DOI: 10.1080/17435390.2018.1513090.
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