What is it about?
This review aimed at identifying the contribution of factors known to be implicated in age-associated mechanisms -such as metabolic deregulation, inflammation and redox imbalance- in osteoarthritis onset and/or progression.
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Why is it important?
Our results outline the causal network of the osteoarthritis and place chondrocytes’ senescence at the center of the emerging aetiopathological atlas.
Perspectives
The vast amount of data that the -omics technologies (genomics, epigenomics, proteomics, metabolomics) generate carries with it great hopes for the development of new and effective therapeutic means. But this quantity of data can lead to a phenomenon that resembles the “street-light effect”, where the drunk man is looking for his keys not in the park where he lost them, but where the light is. Our approach in this review, on the other hand, where by clustering the data we reveal the chondrocytes’ senescence-associated nature of many of the identified molecular players, could prove beneficial for the pursuit of direction. And this could provide a sound basis for future lines of research as well as treatment.
Varvara Trachana
University of Thessaly
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This page is a summary of: Understanding the role of chondrocytes in osteoarthritis: utilizing proteomics, Expert Review of Proteomics, January 2019, Taylor & Francis,
DOI: 10.1080/14789450.2019.1571918.
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