What is it about?
This publication discusses how healthcare professionals can optimize the use of antibiotics in critically ill patients when advanced tools like Therapeutic Drug Monitoring (TDM) are unavailable. It provides practical advice for tailoring antibiotic treatments based on the patient's unique health conditions and challenges, such as organ failure, weight changes, or infections with drug-resistant bacteria. The goal is to ensure effective treatment while minimizing drug resistance and side effects.
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Why is it important?
This work is crucial because it provides practical solutions for managing antibiotic therapies in real-world settings where advanced monitoring tools like TDM are often unavailable. By focusing on common clinical challenges and offering evidence-based strategies, it empowers healthcare providers to improve patient outcomes, reduce treatment failures, and combat the growing threat of antimicrobial resistance.
Perspectives

This publication reflects my commitment to addressing real-life challenges faced by clinicians in managing antibiotic therapy for critically ill patients. The lack of access to Therapeutic Drug Monitoring in many centers inspired me to explore alternative, practical strategies for optimizing antibiotic use. I hope this work provides valuable insights and actionable guidance to healthcare professionals, helping to improve patient outcomes while mitigating the risk of antimicrobial resistance.
Professor Stefano Di Bella
Universita degli Studi di Trieste
Read the Original
This page is a summary of: ‘Real-life’ approach to applying PK/PD principles in infectious diseases clinical practice without access to prompt TDM, Expert Review of Anti-infective Therapy, January 2025, Taylor & Francis,
DOI: 10.1080/14787210.2024.2448727.
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Contributors
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