Insulin, CML , sRAGE, and markers of inflammation and oxidative stress in a normal pregnancy.

What is it about?

Normal pregnancy is accompanied by insulin resistance (IR) and significant increase in lipid profile, and there are little information on the AGE-RAGE axis during pregnancy and this work demonstrates that circulating levels of CML and sRAGE decreased significantly at the end of pregnancy

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Why is it important?

Our study confirms that normal pregnancy is accompanied by insulin resistance (IR) and significant increase in lipid profile, and demonstrates that circulating levels of CML and sRAGE decreased significantly at the end of pregnancy. The lack of association between the course of insulin levels and those of CML probably results from the predominant role of placental factors in the pathogenesis of IR in pregnancy. sRAGE levels in the neonates are markedly increased compared to their mothers suggesting a placental origin of this compound which may have a protective effect on the fetus since sRAGE restricts Advanced glycation end product (AGE) effects and may exert anti-inflammatory effects.

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