What is it about?
Fc receptor-like (FCRL) molecules, as recently identified members of the immunoglobulin superfamily (IgSF), are preferentially expressed by B-cells and get involved in different aspects of B-cell biology and pathology such as B-cells development, differentiation, activation, antibody secretion and isotype switching. and basically involved in B-cell signaling.
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Why is it important?
Recent investigations on different family members of FCRL proteins have highlighted their differential expression and function in numerous immune-disorders including B-cell malignancies, infectious diseases, allergy and autoimmune diseases.
Perspectives
These data suggest novel potential pharmacological targets and logical candidates for the development of antibody- and cell-based immunotherapy approaches in B-cell malignancies, immune-mediated and infectious diseases.
Mahdi Shabani
Shahid Beheshti University of Medical Sciences
Read the Original
This page is a summary of: Update on Fc receptor-like (FCRL) family: new immunoregulatory players in health and diseases, Expert Opinion on Therapeutic Targets, May 2018, Taylor & Francis,
DOI: 10.1080/14728222.2018.1472768.
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