T lymphocytes in the third trimester decidua in preeclampsia

What is it about?

• We examined the number of CD3+ and CD8+ decidual T lymphocytes in preeclampsia • A higher number of CD3+ and CD8+ T lymphocytes was present in preeclamptic decidua • A higher share of CD8+ in the number of CD3+ T cells was present in preeclampsia • In preeclampsia with IUGR there was more CD3+ and CD8+ cells than in that without it • The immune milieu of decidua is of importance in etiopathogenesis of preeclampsia

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Why is it important?

Problem: Preeclampsia is a very serious disorder in pregnancy, but still not completely clarified. Method of Study: A prospective case-control study included a study group of 30 pregnant women with preeclampsia (19 of them with IUGR and 11 without it) and a control group of 20 healthy pregnant women. Samples of placental bed obtained during the Caesarean section were analyzed after immunohistochemical staining of CD45+ leukocytes, CD3+ and CD8+ T-lymphocytes. Results: The group with preeclampsia included significantly higher number of CD3+ T-lymphocytes (p<0.01), CD8+ T lymphocytes (p<0.05), as well as the share of CD8+ in the number of CD3+ T cells (72.8% compared to 66.2%; p<0.05). The subgroup of preeclampsia with IUGR compared to the one without it had a significantly greater presence of CD3+ and CD8+ T lymphocytes. Conclusions: It is certain that the balance dysregulation of T cell of the immune milieu of decidua is of importance in etiopathogenesis and manifestations of preeclampsia.

Perspectives