Antibiofilm and antivirulence property of reserpine.

What is it about?

Among the virulence traits, biofilm plays a critical role in the pathogenicity of Pseudomonas aeruginosa, an opportunistic pathogen of human health concern, by enhancing its resistance to conventional drugs. Thus the present therapeutic strategies are becoming limited to combat drug-resistant strains as well as bacterial biofilm formation. The emergence of resistance against conventional drug among pathogenic bacterial strains force scientists to identify and implement more alternative strategies to control infectious diseases as some of the pathogens seem to be more threatening if they switch to biofilm state. In this context, our current studies on reserpine demonstrate its negative effect on several biofilm-related traits like EPS formation, cell viability and motility, various virulence factors, and on biofilm-controlled genes.

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Why is it important?

In the perspective of new antibacterial drug development, reserpine might be considered as a new lead to generate other analogues with improved pharmacological properties, which warrants further study.