What is it about?
The study reports the activator function of a natural compound on HK4, an isoform of hexokinase present in the liver and pancreas, using computational approach (molecular docking and molecular dynamics simulation) and experimental validation.
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Why is it important?
A natural compound is reported to activate HK4 which may be useful in diabetes.
Perspectives
HK4 is an isozyme in glucose metabolism the activation of which lowers the blood glucose level, without the risk of hypoglycemia.
Dr. Shakir Ali
Jamia Hamdard
Read the Original
This page is a summary of: Computational prediction and experimental validation of the activator function of C2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone on pancreatic and hepatic hexokinase, Journal of Biomolecular Structure and Dynamics, August 2019, Taylor & Francis,
DOI: 10.1080/07391102.2019.1650829.
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