What is it about?
In the current study, bioinformatics approaches were used to predict antigenic, immunogenic, non-allergenic and conserved B and T-cell epitopes as promising targets to design an effective peptide-based vaccine against dengue virus. Molecular docking analysis indicated the deep binding of the identified epitopes in the binding groove of the most popular human MHC I allele (HLA A*0201). The final vaccine construct was created by conjugating the B and T-cell identified epitopes using proper linkers and adding an appropriate adjuvant at the N-terminal.
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Why is it important?
It is a serious public health problem in subtropical and tropical countries. There is no a specific vaccine currently available for clinical use and study on this issue is ongoing. In the current study, bioinformatics approaches were used to predict antigenic, immunogenic, non-allergenic and conserved B and T-cell epitopes as promising targets to design an effective peptide-based vaccine against dengue virus.
Perspectives
The study results indicated the high potential capability of the new multi-epitope vaccine to induce cellular and humoral immune responses against the dengue virus. Further experimental tests are required to investigate the immune protection capacity of the new vaccine construct in animal models.
Soudabeh Sabetian
Read the Original
This page is a summary of: Exploring Dengue Proteome to Design an Effective Epitope-Based Vaccine against Dengue Virus, Journal of Biomolecular Structure and Dynamics, July 2018, Taylor & Francis,
DOI: 10.1080/07391102.2018.1491890.
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