What is it about?
This review gives a general idea about the importance of chiral carbon in medicine and a way to obtain chiral building blocks with Baker’s yeast (Saccharomyces cerevisiae) or synthesis of medicaments and other organic compounds. Reactions with these microorganisms are cheaper and easier to be executed than with chemicals (e.g., organometallics). Examples of important and practical reactions catalyzed by enzymes inside Saccharomyces cerevisiae are given and probable mechanisms of action of these enzymes are shown. Although these microbes have advantages such as low cost and availability, there are some concerns that are necessary to be resolved, such as NAD(P)H dosage to choose strains more adequate for reduction reactions.
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Why is it important?
Saccharomyces cerevisiae is used by organic chemists to generate chiral centers as part of synthesis of chiral medications.
Perspectives
This paper was the base for generate news molecules.
Ricardo de Souza Pereira
Universidade Federal do Amapa
Read the Original
This page is a summary of: The Use of Baker's Yeast in the Generation of Asymmetric Centers to Produce Chiral Drugs and Other Compounds, Critical Reviews in Biotechnology, January 1998, Taylor & Francis,
DOI: 10.1080/0738-859891224211.
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