What is it about?
Thiolated polymers are widely used and one of the feasible means of the controlled release drug delivery system. In the present study, we have shown the superiority of mucoadhesive film in the delivery of bisphosphonate derivative for control and treatment of glucocorticoid-induced osteoporosis in a rat model.
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Why is it important?
Risedronate sodium is a bisphosphonate derivative having very low bioavailability when administered through the oral route. Moreover, the adverse effects associated with the drug when administered through GIT necessitate an alternative and feasible route which can improve its bioavailability and therapeutic efficacy. So, in the present study, we have used a biodegradable thiolated polymer-based drug delivery system, which can deliver the drug in a controlled manner directly into the systemic circulation, thereby avoiding the adverse effects associated with the drug in oral delivery and also opens up an alternative treatment option to patients with osteoporosis.
Perspectives
It was a great teamwork by all the co-authors while performing the lab work and also making the manuscript for publication. We the authors sincerely hope that the work makes a lot of impact in the world of medicine and drug delivery.
Dr Dhrubojyoti Mukherjee
MS Ramaiah University of Applied Sciences
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This page is a summary of: Improvement of bone microarchitecture in methylprednisolone induced rat model of osteoporosis by using thiolated chitosan-based risedronate mucoadhesive film, Drug Development and Industrial Pharmacy, September 2018, Taylor & Francis,
DOI: 10.1080/03639045.2018.1503297.
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