Choline- versus imidazole-based ionic liquids as functional ingredients in topical delivery systems.

What is it about?

Five different Ionic Liquids (ILs) were prepared—three imidazole-based ILs and two choline-based ILs and their cytotoxicity in human keratinocytes (HaCat cells), their influence in drug solubility and in percutaneous permeation, using pig skin membranes, was evaluated. The more suited Its were incorporated in topical formulations, allowing a higher drug loading.

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Why is it important?

Our results indicate that the choline-based Ionic Liquids were effective functional ingredients, since, when used at nontoxic concentrations, they allowed a higher drug loading, while maintaining the stability of the prepared formulations.