What is it about?
The synthesized thioureas, 1-(3-fluorobenzoyl))-3-(4-(diethyl aminophenyl) thiourea (I1), 1-benzoyl-3-(2-chlorophenyl) thiourea (I2) and 1-(2-fluorobenzoyl)-3-(2-chlorophenyl) thiourea (I3) along with triphenylphosphine were reacted with Cu(I) chloride in mole ratios 1:2:1 by using dry acetone as solvent under nitrogen to get 1–3. The synthesized thioureas and metal derivatives were characterized by spectroscopic techniques such as IR and multinuclear (1H, 13C) NMR. Compound 3 is analyzed by single crystal X-ray analysis and data reveal that the Cu is four coordinate having tetrahedral molecular geometry. The interaction of 1–3 with DNA is ascertained by cyclic voltammetry, determining binding constant, binding energy and diffusion coefficient. The findings suggest that the complexes interact with DNA in an electrostatic mode. The antioxidant activity data show that 3 has the highest free radical scavenging ability having Ic50 value of 10 mg/mL. The synthesized compounds were also screened against various bacterial strains and found some encouraging results. The binding interactions of the metal complexes with a specific protein were further validated by molecular docking studies and the results obtained show their strong interaction with amino acid residue in the binding pocket of the target protein.
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Why is it important?
Among trace metals, copper plays an important role in the development and performance of nerve, cardiovascular, immune and reproductive systems besides the nourishment of skin, bones as well as gene transcription of humans. Copper forms a wide range of coordination complexes in both I and II oxidation states; copper(III) complexes have been rarely reported . In comparison to Cu(II) coordination compounds of Cu(I) are less common but are more interesting in terms of their structural and biological aspects
Perspectives
Compounds having carbonyl and thiocarbonyl functionalities behave as versatile donor ligands for transition metal ions . Derivatives of thiourea are well known for their intra- and intermolecular hydrogen bonding capabilities. They are also used as important ligands in coordination chemistry with potential to coordinate with various metal ions as mono or dianions, or as neutral ligands . Thioureas with these added properties are used in self-assembled network materials.The nitrogen, sulfur and oxygen donors of thioureas and their derivatives provide various possibilities to coordinate with transition metal ions to yield useful chemical products. Thioureas as well as their metal complexes have been screened for a variety of biological activities and are important because of their special role in biological systems [14–17]. Some thiourea derivatives have also been used as fungicides on a commercial scale.
Dr Imtiaz-ud-Din - Din
Quaid-i-Azam University
Read the Original
This page is a summary of: New bioactive Cu(I) thiourea derivatives with triphenylphosphine; synthesis, structure and molecular docking studies, Journal of Coordination Chemistry, April 2020, Taylor & Francis,
DOI: 10.1080/00958972.2020.1771558.
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