Benzylideneamino-3,5-dimethyl-1H-pyrazoles

What is it about?

Multi-component reactions (MCRs) are convergent reactions, in which three or more starting materials react to form a complex product, where basically all or most of the atoms contribute to the newly formed single product. In an MCR, a product is assembled according to a cascade of elementary chemical reactions. Multi-component reactions play an insignia part in organic chemistry because they produce the maximum yield of product and selectivity, at the same time produce very fewer by-products compared to stepwise synthesis. Additionally, multi-component reactions are operationally simple, less expensive, rapid, economical and involve easy experimental procedures.

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Why is it important?

Triazole and its heterocyclic compounds exhibit many biological activities, such as antimicrobial, anti-HIV, CNS-stimulatory, antivirus, analgesic, and antifungal activities. Likewise, there are known drugs consisting of the triazole ring, e.g., Triazolam, Alprazolam, Etizolam, and Furacylin. Pyrazoles are heterocyclic compounds with two nitrogen atoms at the adjacent position and there are different procedures for the synthesis of pyrazoles. Pyrazole derivatives are associated with antimicrobial, analgesic, immunosuppressive, anticancer, anti-diabetic and anti-inflammatory activity