What is it about?
This study examined the in vitro effects of a D‑pinitol–rich methanolic extract from Glycyrrhiza glabra leaves (GGLME) on palmitate‑induced hypertrophic 3T3‑L1 adipocytes. The extract was compared directly with pure D‑pinitol. Pretreatment with GGLME reduced lipid accumulation and lowered PPAR‑γ expression and NF‑κB activation induced by palmitate. The extract also improved insulin sensitivity, both with and without palmitate, increasing PI3K, pAkt, and GLUT1 levels. The effects were similar to those observed with D‑pinitol alone. The results suggest that licorice leaves—often considered an agricultural byproduct—contain bioactive components with potential metabolic relevance.
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Why is it important?
Palmitate‑induced adipocyte hypertrophy models key features of metabolic dysfunction, including inflammation and impaired insulin signaling. Demonstrating that a pinitol‑rich extract counteracts these alterations highlights the potential value of Glycyrrhiza glabra leaves as a bioactive resource. The observed improvements in PI3K/Akt/GLUT1 signaling, alongside reductions in NF‑κB activity, align with mechanisms relevant to insulin resistance and adipose inflammation—central contributors to metabolic disorders. The study also supports the idea of valorizing plant materials typically regarded as waste.
Perspectives
These findings are based on in vitro experiments in 3T3‑L1 adipocytes; in vivo studies are needed to evaluate bioavailability, metabolism, and effective doses in physiological systems. Future research should clarify the contribution of pinitol relative to other phytochemicals present in the extract, assess effects in additional adipocyte models, and explore interactions with dietary lipids. The potential use of licorice leaf extracts as nutraceutical candidates requires further evaluation of safety, metabolic stability, and long‑term activity.
Prof. Antonio Speciale
University of Messina
Read the Original
This page is a summary of: Effects of a pinitol-rich Glycyrrhiza glabra L. leaf extract on insulin and inflammatory signaling pathways in palmitate-induced hypertrophic adipocytes, Natural Product Research, November 2021, Taylor & Francis,
DOI: 10.1080/14786419.2021.2010073.
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