What is it about?
This study evaluated a methanolic extract from Glycyrrhiza glabra (licorice) leaves—naturally rich in D‑pinitol and polyphenols—for its potential to counteract endothelial dysfunction associated with insulin resistance. The extract was characterized through polyphenol profiling and quantification of D‑pinitol by HPLC‑ELSD and NMR. In human umbilical vein endothelial cells (HUVECs) exposed to palmitic acid, a major circulating saturated fatty acid, the leaf extract protected the insulin signaling pathway. Its effects were comparable to those observed with pure D‑pinitol, suggesting that the phytocomplex can mitigate lipotoxicity‑driven impairment of endothelial function.
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Why is it important?
Endothelial dysfunction is a hallmark of metabolic disease and is strongly influenced by lipotoxicity and impaired insulin signaling. Demonstrating that licorice leaf extracts support insulin responsiveness in endothelial cells highlights their potential value in metabolic health. Because licorice leaves are typically considered an agricultural waste product, identifying them as a source of bioactive compounds—particularly D‑pinitol—supports their reutilization as cost‑effective nutraceutical ingredients. The extract may represent a sustainable alternative to more expensive sources of pinitol such as carob.
Perspectives
The results derive from an in vitro endothelial model; further in vivo studies are needed to determine bioavailability, metabolic stability, and effective doses. It will also be important to define whether D‑pinitol is the main active component or whether synergistic interactions within the phytocomplex contribute to the protective effects. Additional research should evaluate long‑term activity, effects in different endothelial models, and the potential relevance for metabolic disorders where endothelial insulin resistance plays a role, including cardiovascular complications, type 2 diabetes, and polycystic ovary syndrome.
Prof. Antonio Speciale
University of Messina
Read the Original
This page is a summary of: A pinitol-rich Glycyrrhiza glabra L. leaf extract as functional supplement with potential in the prevention of endothelial dysfunction through improving insulin signalling, Archives of Physiology and Biochemistry, June 2020, Taylor & Francis,
DOI: 10.1080/13813455.2020.1764046.
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