Shooting many cytokines by a single inhibitor, but not randomly with target specificity.

What is it about?

The one-to-one correspondence between components in Biology (i.e., one gene, one protein, one function, one disease) becoming obsolete. We now know many examples in which many genes/proteins cooperate in causing one human disease. This alters the way we develop interventions in treating human diseases. We saw a need to develop a new technology by which to inhibit many biological factors (i.e., hormones, cytokines) with structural and functional similarities so we can cure human diseases. This paper presents a successful example of such attempts, including the rational, strategy and execution.

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Why is it important?

Clinical interventions in treating human diseases tend to only focus on inhibiting one component (a gene, a protein). However, we are now aware that such case (one factor is causing a disease) only represents a fraction of all human disorders. We also do not have many options to treat diseases in which multiple-factors are involved without causing serious adverse situations. This work addressed the issue and presents an innovative solution.