What is it about?
Class I Myosins link plasma membrane and actin cytoskeleton we described a PH domain at the tail of all class I myosins and extra residues that contribute to membrane binding
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Why is it important?
Plasma membrane and actin cytoskeleton attachment is a regulated process, the cell has to be able to change shape to migrate or to secrete or ingest material, class I myosins control different aspects of those functions
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This page is a summary of: Myosin 1G Is an Abundant Class I Myosin in Lymphocytes Whose Localization at the Plasma Membrane Depends on Its Ancient Divergent Pleckstrin Homology (PH) Domain (Myo1PH), Journal of Biological Chemistry, January 2010, American Society for Biochemistry & Molecular Biology (ASBMB),
DOI: 10.1074/jbc.m109.086959.
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