What is it about?
Mutations can do different things to proteins. Often, a mutation supercharges a protein’s function, but a mutation can also change which other biomolecules a protein interacts with. The protein we study has a mutation that was known to enhance protein function. We have found that it also changes the protein community, which means it supercharges only specific protein functions.
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Why is it important?
This discovery helps us understand our protein better, by showing the different ways in which mutations can change protein behavior. Understanding this protein can help us design treatments for diseases associated with these mutations.
Read the Original
This page is a summary of: The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain, Proceedings of the National Academy of Sciences, July 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2407159121.
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