What is it about?
Our team has identified a non-natural retinal analog that can activate a bistable opsin from jumping spiders without light. This analog allows us to investigate how the molecular basis of vision differs in vertebrates and invertebrates, and may help us to understand how our visual systems evolved.
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Why is it important?
Opsins are responsible for invertebrate vision and regulation of circadian rhythms in mammals. The analogs will help us study light perception in animals.
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This page is a summary of: Activating an invertebrate bistable opsin with the all-trans 6.11 retinal analog, Proceedings of the National Academy of Sciences, July 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2406814121.
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