What is it about?
We discovered a mouse model that allows non-invasive ablation of choroid plexus ablation in adult mouse brains which leads to loss of CSF and decreased newly born immature neurons in the brain parenchyma.
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Photo by Milad Fakurian on Unsplash
Why is it important?
CSF can have many important functions but tools to manipulate choriod plexus and CSF in the adult brain are limited. This mouse line allows us to directly test the function of the choroid plexus and CSF in many important brain functions and biological processes. Our results suggest an important function of CSF is to maintain the reparative capacity of the brain after injury.
Perspectives
This work also warrants careful interpretation and reevaluation of previous studies using this ROSA26iDTR mouse line to ablate specific cell types, not just in the brain but in many other organs and tissues. However, now we have a very cool tool to study adult ChP and CSF. We are currently using this model to study neurodegeneration. This was a serendipitous discovery and reminds me how unexpected and fun science can be!
Agnes Luo
University of Cincinnati
Read the Original
This page is a summary of: The choroid plexus maintains adult brain ventricles and subventricular zone neuroblast pool, which facilitates poststroke neurogenesis, Proceedings of the National Academy of Sciences, July 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2400213121.
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