What is it about?
Hedgehog (Hh) signaling, an evolutionarily conserved pathway, plays essential roles in development and tumorigenesis, making it a promising drug target. This study elucidates a responsible mechanism and its regulator, filling a critical gap in activation of Hedgehog signaling.
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Why is it important?
Our findings of a novel regulatory mechanism of Hh signaling expands understanding of control of Hh-associated diseases.
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This page is a summary of: Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase, Proceedings of the National Academy of Sciences, July 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2320070121.
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