What is it about?
This study reveals a novel function of a known anti-cancer protein in suppressing lung cancer growth by inhibiting an important oncoprotein called "c-Myc" via a unique way.
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Why is it important?
This known anti-cancer protein is called "RBM10" that stands for RNA binding protein 10, a member of a big family in our human body. Its gene is often altered in human lung cancers as well as other types of cancers to lose its ability to suppress cancer cell growth. This study also found out that one of the altered protein products can promote lung cancer growth, instead of suppressing cancer growth. Thus, this finding along with the findings as mentioned above is clinically significant.
Perspectives
Our findings also suggest a new potential target for developing anti-cancer therapeutic approaches against lung cancers that harbor this mutated RMB10 protein.
Hua Lu
Tulane University
Read the Original
This page is a summary of: RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5, Proceedings of the National Academy of Sciences, November 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2308292120.
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