What is it about?
We have uncovered a novel population of CD8+ T cells endowed with potent tumoricidal capabilities. The distinguishing hallmark of these cells lies in their capacity to circumvent a quandary intrinsic to current T cell-based tumor immunotherapeutic strategies. Namely, the vast diversity in MHC molecules across human populations leads to an inherent incompatibility between T cells derived from distinct individuals. Consequently, these T cells hold the promise of establishing an "off-the-shelf" approach to T cell-based tumor therapy.
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Why is it important?
Our findings show that a small population of T cells can be stimulated to exert strong anti-tumor effects. Thus, we could establish tumor immunotherapy based on this T cell population.
Perspectives
This population of T cells harbors the potential to establish "off-the-shelf" tumoricidal T cell products, thereby inaugurating a novel research avenue in the field of T cell-based tumor immunotherapy.
Qing Li
Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Read the Original
This page is a summary of: MHC class Ib–restricted CD8
+
T cells possess strong tumoricidal activities, Proceedings of the National Academy of Sciences, October 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2304689120.
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