What is it about?
We identified an epigenetic regulatory mechanism that is important for maintaining the health of intestinal cells and protect them from stressors such as pathogenic bacteria and toxic chemicals.
Featured Image
Photo by julien Tromeur on Unsplash
Why is it important?
The finding of an epigenetic program that functions to protect the intestinal epithelial lining from luminal stressors could serve as platform to develop new treatments to maintain gastrointestinal health.
Perspectives
This article highlights the need to further define the role of DNA oxidations as epigenetic determinants to restructure gene expression patterns in intestinal epithelial cells to maintain and protect gut health.
Assistant Professor Jean-Pierre Etchegaray
Rutgers University Newark
Read the Original
This page is a summary of: TET3-mediated DNA oxidation is essential for intestinal epithelial cell response to stressors, Proceedings of the National Academy of Sciences, September 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2221405120.
You can read the full text:
Contributors
The following have contributed to this page
