What is it about?
Intraocular pressure is the pressure of fluid inside the eye. The trabecular meshwork is a sieve-like structure responsible for draining the fluid from the eye. The resistance to fluid outflow is increased in glaucoma, thereby elevating intraocular pressure. We show that a cell membrane protein in the trabecular meshwork, called TRPV4, decreases the resistance to fluid outflow and lowers intraocular pressure. Moreover, TRPV4 dysfunction in the trabecular meshwork contributes to elevated intraocular pressure in glaucoma.
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This page is a summary of: Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma, Proceedings of the National Academy of Sciences, April 2021, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2022461118.
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