Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity

What is it about?

The binding site of an antibody could be obscured by a post-translation modification - glycosylation. So any hypermutation of an antibody in the germinal centre that affects a potential glycosylation site could affect antibody binding and therefore could moderate the positive and negative selection processes that a B cell has to pass through.

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