What is it about?
This mouse line has a thyroid hormone receptor that carries a mutation R429Q. This mutation was though before to be responsible for the Central form of the human syndrome of resistance to thyroid hormone. However, in the mouse model, we showed that the mice are affected different concerning negative and positive regulation by T3.
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This manuscript impacts the clinic.
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This page is a summary of: A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo, Proceedings of the National Academy of Sciences, June 2009, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.0903227106.
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