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Replacing the vif gene of HIV-1 with that of SIV led to efficient replication in pigtailed macaques. Plasma viremia could be increased by depletion of CD8+ T cells and could be suppressed prophylactically by treatment with combination antiretroviral therapy.
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This page is a summary of: A macaque model of HIV-1 infection, Proceedings of the National Academy of Sciences, March 2009, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.0812587106.
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