What is it about?
The study shows how brain pulsations that drive brain fluid circulation are affected in relation to differing states of orexin activity by comparing awake and sleeping controls, and narcolepsy type 1 patients. We further validate the used method in a phantom model.
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Why is it important?
The study links narcolepsy type 1, orexin and arousal state to changes in the forces driving human brain fluid dynamics shedding insight on the neurophysiological phenomena of brain clearance.
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This page is a summary of: Orexin effect on physiological pulsations of the human brain, Proceedings of the National Academy of Sciences, August 2025, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2501578122.
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