What is it about?
Aldosterone is a steroid hormone key to controlling blood pressure. Our results suggest a novel mechanism underlying the cooperation between two closely-related steroid hormone receptors, MR and GR, to potentiate the effects of aldosterone on controlling gene expression .
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Why is it important?
The possible functional interaction between two closely-related steroid hormone receptors, the glucocorticoid and the mineralocorticoid receptors, has long been proposed, but its physiological relevance on the control of gene expression and in regulating the signals of the hormone aldosterone was unclear. We now show the prominent role of this interaction in aldosterone cellular effects and propose molecular mechanisms that may explain this phenomenon, as well as other interactions between related steroid receptors.
Perspectives
I hope this article sheds light on the often-overlooked area of cooperation between steroid receptors and the molecular mechanisms that may be involved in their interaction.
Diego Alvarez de la Rosa
Universidad de La Laguna
Read the Original
This page is a summary of: The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor, Proceedings of the National Academy of Sciences, November 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2413737121.
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