What is it about?

Recordings of the electrical activity of individual neurons in humans are exceedingly rare. Therefore, most of what we know about the functioning of the brain at the level of single neurons is derived from studies in animals. This paper presents the results of exceptional recordings in two epilepsy patients, who were implanted with electrodes in their brain to localize the source of their seizures. The authors show that neurons in a specific area of the human brain respond strongly to images of bodies and body parts, and even to simple stick figures depicting a human body.

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Why is it important?

Imaging studies in human volunteers had already suggested the presence of an area in the human brain that is specifically involved in the visual processing of images of bodies. This study provides crucial validation of this hypothesis at the level of individual neurons for the previous imaging studies, and bridges the gap between imaging studies in humans and single-cell recordings in monkeys. The study clearly demonstrates that the properties of neurons responding to bodies and body parts in humans are virtually identical to the ones of neurons previously recorded in our closest relative, the macaque monkey. Therefore, it also supports the validity of this animal model in visual neuroscience.

Perspectives

Future studies should seize the opportunity to record the responses of individual neurons in epilepsy patients because this is the only way we can relate the findings obtained with imaging to the results obtained in numerous invasive studies in animal models.

Professor Peter Janssen
Katholieke Universiteit Leuven

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This page is a summary of: Intracortical recordings reveal the neuronal selectivity for bodies and body parts in the human visual cortex, Proceedings of the National Academy of Sciences, December 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2408871121.
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