What is it about?
GPCRs are crucial environmental sensors positioned within cellular membranes. We show for the first time that the ends of these molecules, which are located inside the cell, can interact directly with the cell membrane in ways that modulate GPCR function and signaling.
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Why is it important?
This previously unappreciated mode of GPCR regulation deepens our understanding of how these important molecules, which form a large class of therapeutic drug targets, are regulated.
Perspectives
This was an exciting collaboration between the Eliezer and Levitz laboratories that started as a slightly crazy idea and turned into a really beautiful story.
David Eliezer
Weill Cornell Medicine
Read the Original
This page is a summary of: Control of G protein–coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains, Proceedings of the National Academy of Sciences, July 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2407744121.
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