Actin-driven synaptic vesicle dynamics enable sustained neurotransmission

What is it about?

This study investigates how synaptic vesicles (SVs) are replenished at the active zone of presynaptic terminals to maintain neurotransmitter release during high neuronal activity. Using advanced imaging techniques, the researchers observed the movement of individual SVs near the presynaptic membrane. Their findings suggest that an actin scaffold controls vesicle movement, ensuring rapid recruitment of new SVs after the initial supply is exhausted. This mechanism supports continuous communication between nerve cells and sheds light on how synaptic activity is maintained at high frequency.

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Photo by Bhautik Patel on Unsplash

Photo by Bhautik Patel on Unsplash