What is it about?
In the study by Harkin et al., the authors have demonstrated the ability to generate "mini-retinas" in a dish using human pluripotent stem cells. In particular, they show that this can be done at 100% efficiency and with high reproducibility, paving the way for greater adoption of these mini-retinas in a dish to be used for disease modeling and drug discovery.
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Why is it important?
The ability to generate retinal tissue from stem cells has been complicated by the lack of reproducibility and consistency from one experiment to the next, making it difficult to make direct comparisons and thereby minimizing their application for translational purposes. By greatly reducing many of these barriers, the study by Harkin et al. brings a much stronger approach for the use of these mini-retinas for disease modeling and drug discovery.
Read the Original
This page is a summary of: A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells, Proceedings of the National Academy of Sciences, June 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2317285121.
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