What is it about?

Anti-cancer drugs are very limited access to reach cancer cell because of various physical-chemical drawbacks of API and biological factors. So that bio-compatible and biodegradable polymers have promoted address the cancer cell by loading of drug

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Why is it important?

Recent global updates indicate a daily increase in the number of people affected by cancer, underscoring the urgent need for advancements in cancer research, particularly in developing effective drug delivery systems. Conventional treatment strategies for hepatocellular carcinoma (HCC) face several limitations, including low aqueous solubility, high drug doses, non-specific targeting of HCC cells, and associated toxicity or side effects. Biodegradable polymer-based nanomedicines present a promising approach to enhance drug uptake by HCC cells. These nanomedicines can prolong drug circulation in the blood, increase retention time, and release the drug specifically at the target site. This review summarizes recent advancements in the design of polymeric nanocarriers for HCC, aiming to overcome the persistent challenges associated with traditional HCC chemotherapy. The various strategies discussed herein provide valuable insights for developing and formulating effective nanomedicine-based treatments for hepatocellular carcinoma.

Perspectives

The physical characteristics, such as the size and shape of particles, play a crucial role in their high voltage and significant velocity when approaching infected cells in biological environments. By engineering surface modifications of polymers and loading drug molecules at the nano level, these polymers can effectively carry and deliver drugs specifically to target cancer cells, sparing healthy cells.

Mr Vothani Sarath Babu
Lovely Professional University

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This page is a summary of: Polymeric nanoparticles based treatment approaches for hepatocellular carcinoma (HCC), January 2023, American Institute of Physics,
DOI: 10.1063/5.0168936.
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