What is it about?
The reaction of indoles with carbonyl compounds in the presence of 5 mol% Meglumine Sulphate (MS) in acetonitrile was executed to synthesize bis(indolyl)methane derivatives using conventional and ultrasonication methods. The reaction proceeded in shorter reaction time in ultrasonication methodology leading to high yield of the products.
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Why is it important?
The reaction of indole (1) with carbonyl compounds (2) in the presence of 5 mol% Meglumine Sulphate as a catalyst in acetonitrile was carried out to obtain bis(indolyl) methane derivatives (3a-e) using conventional and ultrasonication methodologies. It was observed that the reaction proceeded in shorter reaction times and in high yield in ultrasonication methodology when compared with the conventional method.
Perspectives
The reaction of indole (1) with carbonyl compounds (2) in the presence of 5 mol% Meglumine Sulphate as a catalyst in acetonitrile was carried out to obtain bis(indolyl) methane derivatives (3a-e) using conventional and ultrasonication methodologies. It was observed that the reaction proceeded in shorter reaction times and in high yield in ultrasonication methodology when compared with the conventional method.
Prof Ratnakaram Venkata Nadh
GITAM University
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This page is a summary of: Meglumine sulphate: An efficient catalyst for the synthesis of bis(indolyl)methanes, January 2020, American Institute of Physics,
DOI: 10.1063/5.0018097.
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