Plasma-Modified PCL Scaffolds for Enhanced Biocompatibility in Tissue Engineering

What is it about?

A study investigates the possibility of using magnetron sputtering to deposit thin titanium-nitrogen coatings on the surface of PCL-based medical devices for cardiovascular surgery. The research examines the influence of different treatment times on the physico-chemical properties and biocompatibility of PCL electrospun scaffolds. The study found that plasma treatment does not change the physico-mechanical properties of electrospun PCL scaffolds, increases their biocompatibility, and increases their hydrophilicity. This method of modifying the scaffold surface opens a route to producing scaffolds with enhanced biocompatibility for tissue engineered vascular grafts.

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Why is it important?

This research is important because it focuses on developing materials and technologies for cardiovascular surgery. The study explores the use of bioresorbable electrospun polycaprolactone (PCL) scaffold surface modification through reactive magnetron sputtering of a titanium target in a nitrogen atmosphere. This modification enhances the biocompatibility of scaffolds for tissue-engineered vascular grafts, potentially improving the outcomes of cardiovascular surgeries. Key Takeaways: 1. The research explores the modification of PCL scaffolds for cardiovascular applications. 2. Plasma treatment with a titanium target in a nitrogen atmosphere increases biocompatibility and hydrophilicity of PCL scaffolds without affecting their physico-mechanical properties.